The XTEND Trial – Xpert for TB: Evaluating a New Diagnostic

In South Africa, the Department of Health is rolling out Xpert MTB/RIF, a new diagnostic test with improved sensitivity for detection of active TB combined with simultaneous detection of rifampicin resistance. The XTEND study is a cluster randomised pragmatic trial ,where 20 laboratories in South Africa, in high burden TB districts are randomised to receive Xpert […]

The Thibela TB Study – A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

The Thibela TB study was a cluster-randomized trial conducted at three gold-mining companies in South Africa. It evaluated a community-wide intervention, which consisted of screening an entire workforce for active tuberculosis and linking that to treatment for those with active disease or a course of isoniazid preventive therapy for those without active disease. The purpose of […]

The ZAMSTAR Study- The Zambia South Africa TB and HIV Reduction Study

The ZAMSTAR program tests ways to interrupt the transmission of TB in communities with a high burden of TB and HIV through additional TB control mechanisms. Twenty-four communities across Zambia and South Africa’s Western Cape Province participated in the study.   ZAMSTAR, The Zambia South Africa TB and HIV Reduction study: Design of a 2 […]