Cluster Randomised Trials

Randomization: Beyond the Closurization Principle

Date: Friday 12th July Time: 15.30 – 16.30 Location: Manson Lecture Theatre, Keppel Street Speaker: Larry Moulton To celebrate the launch of a new short course on the design and analysis of cluster randomised and stepped wedge trials, the centre for evaluation is hosting a seminar from Professor Larry Moulton. This presentation focuses on the randomization of […]

Challenges in reducing HIV and TB stigma among healthcare workers in the workplace: Results and insights from the “HIV and TB Stigma among Health Care Workers (HaTSaH) Study” a South African cluster randomised trial

Date: Wednesday 1st May Time: 12.45 – 14.00 Venue: Jerry Morris B, Tavistock Place Speaker: Nina Sommerland HIV and TB stigma among co-workers in hospitals can have severe implications. Healthcare workers (HCW) might delay or avoid seeking care out of fear of being stigmatised at work, causing increased morbidity and mortality and putting further strain on an overburdened health […]

Impact of universal test-and-treat on HIV incidence in Zambia and South Africa: Results of the HPTN 071 (PopART) trial

Date: Thursday 9th May 2019 Time: 12:30 – 13:30 Venue: John Snow A Lecture Theatre, Keppel Street Speaker: Professor Richard Hayes PopART was a cluster-randomised trial carried out in 21 communities in Zambia and the Western Cape of South Africa, and the largest HIV prevention trial ever undertaken. Richard Hayes, who led the trial, will present the primary results […]

Short course: Design & Analysis of Cluster Randomised and Stepped Wedge Trials

Course dates: 8 to 12 July 2019 Deadline to apply: 31 May 2019 This course will provide attendees with a clear understanding of the design and analysis of cluster randomised trials and stepped wedge trials. This includes the rationale for using these designs, specific design issues, the randomisation process, sample size calculations, analytical methods, ethical […]

The XTEND Trial – Xpert for TB: Evaluating a New Diagnostic

In South Africa, the Department of Health is rolling out Xpert MTB/RIF, a new diagnostic test with improved sensitivity for detection of active TB combined with simultaneous detection of rifampicin resistance. The XTEND study is a cluster randomised pragmatic trial ,where 20 laboratories in South Africa, in high burden TB districts are randomised to receive Xpert […]

The Thibela TB Study – A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

The Thibela TB study was a cluster-randomized trial conducted at three gold-mining companies in South Africa. It evaluated a community-wide intervention, which consisted of screening an entire workforce for active tuberculosis and linking that to treatment for those with active disease or a course of isoniazid preventive therapy for those without active disease. The purpose of […]

The PRIME Trial – A complex intervention to improve malaria care at public health centres in Uganda

In Uganda, health system challenges limit access to good quality healthcare and contribute to slow progress on malaria control. A complex intervention (PRIME) was developed, which was designed to improve quality of care for malaria at public health centres.   The Impact of an Intervention to Improve Malaria Care in Public Health Centers on Health Indicators […]

The MANAS Trial – A cluster randomised controlled trial of a stepped care intervention for common mental disorders (CMD) delivered by lay health workers

Depression and anxiety disorders are common mental disorders worldwide. The MANAS trial aimed to test the effectiveness of an intervention led by lay health counsellors in primary care settings to improve outcomes of people with these disorders.   The impact of a lay counsellor led collaborative care intervention for common mental disorders in public and […]

The SASA! Study – A cluster randomised trial of a community mobilisation intervention to prevent violence against women and reduce HIV risk in Kampala, Uganda

SASA! is a community mobilization approach developed by Raising Voices to help reduce the spread and frequency of violence against women and children. The SASA! study is a collaboration between the London School of Hygiene and Tropical Medicine, the Center for Domestic Violence Prevention (CEDOVIP), Raising Voices, and Makerere University, which aims to asses the impact of […]

IMAGE – Intervention with Micro-finance for AIDS and Gender Equity

IMAGE is a programme in rural South Africa that combines micro-finance with HIV and gender education called Sisters For Life (SFL) to transform gender norms and empower women aiming to reduce risk of gender based violence and HIV.     Process evaluation of the Intervention with Microfinance for AIDS and Gender Equity (IMAGE) in rural South Africa Hargreaves […]