Projects

Evaluation of Nepal Family Planning Programme strengthening

This very large project evaluated various innovations within the Nepal Family Planning Programme over three years. Click here for a complete list of outputs. Unusually, evaluation of one component was particularly focused on qualitative data collection because existing features of the programme meant that we were very restricted in terms of possible designs. The qualitative […]

The XTEND Trial – Xpert for TB: Evaluating a New Diagnostic

In South Africa, the Department of Health is rolling out Xpert MTB/RIF, a new diagnostic test with improved sensitivity for detection of active TB combined with simultaneous detection of rifampicin resistance. The XTEND study is a cluster randomised pragmatic trial ,where 20 laboratories in South Africa, in high burden TB districts are randomised to receive Xpert […]

The Thibela TB Study – A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

The Thibela TB study was a cluster-randomized trial conducted at three gold-mining companies in South Africa. It evaluated a community-wide intervention, which consisted of screening an entire workforce for active tuberculosis and linking that to treatment for those with active disease or a course of isoniazid preventive therapy for those without active disease. The purpose of […]

The MACH project – Meta-analysis, Complexity and Heterogeneity

The project is developing guidance for systematic reviewers when making a decision about whether or not to use a meta-analytical approach to the synthesis of quantitative evidence, with a particular emphasis on the synthesis of studies of complex interventions. This a collaboration between LSHTM, the EPPI Centre, the University of Warwick and the University of York […]

The PRIME Trial – A complex intervention to improve malaria care at public health centres in Uganda

In Uganda, health system challenges limit access to good quality healthcare and contribute to slow progress on malaria control. A complex intervention (PRIME) was developed, which was designed to improve quality of care for malaria at public health centres.   The Impact of an Intervention to Improve Malaria Care in Public Health Centers on Health Indicators […]

The MANAS Trial – A cluster randomised controlled trial of a stepped care intervention for common mental disorders (CMD) delivered by lay health workers

Depression and anxiety disorders are common mental disorders worldwide. The MANAS trial aimed to test the effectiveness of an intervention led by lay health counsellors in primary care settings to improve outcomes of people with these disorders.   The impact of a lay counsellor led collaborative care intervention for common mental disorders in public and […]

The SASA! Study – A cluster randomised trial of a community mobilisation intervention to prevent violence against women and reduce HIV risk in Kampala, Uganda

SASA! is a community mobilization approach developed by Raising Voices to help reduce the spread and frequency of violence against women and children. The SASA! study is a collaboration between the London School of Hygiene and Tropical Medicine, the Center for Domestic Violence Prevention (CEDOVIP), Raising Voices, and Makerere University, which aims to asses the impact of […]

The PROCESS Study – A protocol to evaluate the implementation, mechanisms of effect and context of an intervention to enhance public health centres in Tororo, Uganda

The PROCESS study uses mixed methods to evaluate the processes, mechanisms of change, and context of the PRIME intervention. The findings of this PROCESS study is interpreted alongside the PRIME trial results which enables a greater ability to generalise the findings of the main trial. The investigators attempt to assess which methods are most informative in such evaluations of complex […]

IMAGE – Intervention with Micro-finance for AIDS and Gender Equity

IMAGE is a programme in rural South Africa that combines micro-finance with HIV and gender education called Sisters For Life (SFL) to transform gender norms and empower women aiming to reduce risk of gender based violence and HIV.     Process evaluation of the Intervention with Microfinance for AIDS and Gender Equity (IMAGE) in rural South Africa Hargreaves […]

IDEAS – Informed Decisions for Actions in Maternal and Newborn Health

IDEAS aims to improve the health and survival of mothers and babies through generating a strong body of evidence to inform policy and practice, working in Ethiopia, North-Eastern Nigeria and the state of Uttar Pradesh in India. IDEAS contribute to the evidence base by using standardised approaches to evaluate maternal and newborn health programmes across multiple projects […]