Cluster Randomised Trials

The XTEND Trial – Xpert for TB: Evaluating a New Diagnostic

In South Africa, the Department of Health is rolling out Xpert MTB/RIF, a new diagnostic test with improved sensitivity for detection of active TB combined with simultaneous detection of rifampicin resistance. The XTEND study is a cluster randomised pragmatic trial ,where 20 laboratories in South Africa, in high burden TB districts are randomised to receive Xpert […]

The Thibela TB Study – A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

The Thibela TB study was a cluster-randomized trial conducted at three gold-mining companies in South Africa. It evaluated a community-wide intervention, which consisted of screening an entire workforce for active tuberculosis and linking that to treatment for those with active disease or a course of isoniazid preventive therapy for those without active disease. The purpose of […]

The PRIME Trial – A complex intervention to improve malaria care at public health centres in Uganda

In Uganda, health system challenges limit access to good quality healthcare and contribute to slow progress on malaria control. A complex intervention (PRIME) was developed, which was designed to improve quality of care for malaria at public health centres.   The Impact of an Intervention to Improve Malaria Care in Public Health Centers on Health Indicators […]

The MANAS Trial – A cluster randomised controlled trial of a stepped care intervention for common mental disorders (CMD) delivered by lay health workers

Depression and anxiety disorders are common mental disorders worldwide. The MANAS trial aimed to test the effectiveness of an intervention led by lay health counsellors in primary care settings to improve outcomes of people with these disorders.   The impact of a lay counsellor led collaborative care intervention for common mental disorders in public and […]

The SASA! Study – A cluster randomised trial of a community mobilisation intervention to prevent violence against women and reduce HIV risk in Kampala, Uganda

SASA! is a community mobilization approach developed by Raising Voices to help reduce the spread and frequency of violence against women and children. The SASA! study is a collaboration between the London School of Hygiene and Tropical Medicine, the Center for Domestic Violence Prevention (CEDOVIP), Raising Voices, and Makerere University, which aims to asses the impact of […]

IMAGE – Intervention with Micro-finance for AIDS and Gender Equity

IMAGE is a programme in rural South Africa that combines micro-finance with HIV and gender education called Sisters For Life (SFL) to transform gender norms and empower women aiming to reduce risk of gender based violence and HIV.     Process evaluation of the Intervention with Microfinance for AIDS and Gender Equity (IMAGE) in rural South Africa Hargreaves […]

The IeDA Study – Integrated eDiagnosis Approach for the management of childhood illnesses at primary health facilities in Burkina Faso

Status: Ongoing Study Start Date: September 2014 Estimated End Date: September 2017 Current adherence to Integrated Management of Childhood Illnesses guidelines is very low in Burkina Faso. A promising new approach involves using tablet computers to guide medical practitioners through the guidelines in real-time during a consultation. The data collected can then be used within cycles of […]

PopART/HPTN071: Universal Test and Treat for HIV Prevention

Status: Ongoing Study Start Date: 2013 Estimated End Date: 2017 PopART / HPTN 071 is a large community-randomised trial that will be carried out in Zambia and South Africa to measure the impact of a universal HIV test-and-treat intervention on population-level HIV incidence. To measure the impact of the intervention, a Population cohort consisting of a random sample of 2,500 […]

The ZAMSTAR Study- The Zambia South Africa TB and HIV Reduction Study

The ZAMSTAR program tests ways to interrupt the transmission of TB in communities with a high burden of TB and HIV through additional TB control mechanisms. Twenty-four communities across Zambia and South Africa’s Western Cape Province participated in the study.   ZAMSTAR, The Zambia South Africa TB and HIV Reduction study: Design of a 2 […]