The Thibela TB Study – A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

The Thibela TB study was a cluster-randomized trial conducted at three gold-mining companies in South Africa. It evaluated a community-wide intervention, which consisted of screening an entire workforce for active tuberculosis and linking that to treatment for those with active disease or a course of isoniazid preventive therapy for those without active disease. The purpose of this intervention was to reduce the burden of tuberculosis. Benefits would accrue both through the indirect effect of mass case finding and treatment (thus reducing transmission) and through the direct protective effect of isoniazid treatment for miners with latent infection.

 

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A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control
Churchyard GJ, Fielding KL, Lewis JJ, Coetzee L, Corbett EL, Godfrey-Faussett P, Hayes RJ, Chaisson RE, Grant AD. A trial of mass isoniazid preventive therapy for tuberculosis control. New England Journal of Medicine. 2014 Jan 23;370(4):301-10.

Thibela TB: design and methods of a cluster randomised trial of the effect of community-wide isoniazid preventive therapy on tuberculosis amongst gold miners in South Africa.
Fielding KL, Grant AD, Hayes RJ, Chaisson RE, Corbett EL, Churchyard GJ. Thibela TB: design and methods of a cluster randomised trial of the effect of community-wide isoniazid preventive therapy on tuberculosis amongst gold miners in South Africa. Contemporary clinical trials. 2011 May 31;32(3):382-92.

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